ENGINEERED TO DOMINATE
Multi-agent synergy for faster onset, deeper penetration, and longer duration. Understanding why MediCaine outperforms single-agent numbing.
WHY MULTI-AGENT?
Single-agent topical anesthetics rely on one pathway to block pain. MediCaine uses multiple agents that attack pain signals through different mechanisms simultaneously — surface blockade, deep tissue penetration, extended duration, and vascular constriction.
The result: faster onset, deeper numbing, longer duration, and reduced bleeding at the treatment site. Each agent amplifies the others through pharmaceutical synergy.
THE INGREDIENTS
Five pharmaceutical agents, each with a specific role in the numbing cascade.
BENZOCAINE 20%
Ester-type local anesthetic that provides rapid surface-level numbing. Blocks sodium channels on contact for immediate relief at the application site. The fastest-acting agent in the BLT formula.
LIDOCAINE 10-30%
The gold standard of local anesthetics. Amide-type anesthetic that penetrates deep tissue layers, delivering reliable, long-lasting numbness. Present in all three MediCaine tiers at varying concentrations — 10% in Pro and Ultra, 30% in Elite.
TETRACAINE 7-10%
Long-duration ester anesthetic with an extended half-life. Enhances depth of nerve block and extends the numbing window significantly beyond what Lidocaine alone achieves. 10% in Pro and Ultra, 7% in Elite.
PRILOCAINE 8%
Fourth-agent amplifier exclusive to the Ultra. Amide anesthetic that works synergistically with the BLT base to achieve maximum potency across all tissue depths. Adds a fourth pathway for comprehensive pain signal blockade.
PHENYLEPHRINE 0.5%
Vasoconstrictor that localizes the anesthetic effect. Constricts blood vessels at the treatment site to reduce bleeding, keep the anesthetic agents concentrated in the target area longer, and extend overall duration.
THREE STRENGTHS, ONE STANDARD
Each strength is engineered for specific procedures and intensity levels.
Triple-Agent BLT
High-Concentration LT
Quad-Agent Maximum BLT+
MEDICAINE VS INDUSTRY STANDARD
ONSET, DEPTH AND DURATION
Providers judge a topical anesthetic on three things: how fast numbing starts, how deep it goes, and how long it lasts. Each agent in the formula is there to move one of those numbers.
ONSET
Benzocaine works at the surface first, so patients feel early numbing while the other agents are still building. A cream base also absorbs faster than an ointment base, which shortens the wait.
DEPTH
Lidocaine is the reliable core and reaches further than benzocaine. Tetracaine is the most potent agent and penetrates deepest. In Ultra, prilocaine alongside lidocaine gives denser, more consistent anesthesia.
DURATION
Tetracaine keeps working after the cream is removed. Phenylephrine narrows local blood vessels, which slows how quickly the anesthetics are carried away from the treatment area.
ESTERS AND AMIDES
Local anesthetics fall into two families. Which family an agent belongs to matters most when screening patients for allergies.
ESTERS: BENZOCAINE, TETRACAINE
Broken down in the blood by plasma cholinesterase. One of their breakdown products, para-aminobenzoic acid (PABA), is associated with most true allergic reactions to local anesthetics. A patient allergic to one ester is generally steered away from the others.
AMIDES: LIDOCAINE, PRILOCAINE
Broken down in the liver. True allergy to amides is rare, which is one reason lidocaine is so widely used. Patients with significant liver impairment need provider judgment on dosing.
WHAT "BENZOCAINE-FREE" MEANS
Elite leaves out benzocaine but still contains tetracaine, which is also an ester. It suits patients who react to benzocaine specifically, not everyone with an ester allergy.
METHEMOGLOBINEMIA
Benzocaine and prilocaine have both been associated with methemoglobinemia, a rare condition that reduces the blood's ability to carry oxygen. Screen for risk factors and use provider judgment before choosing a formula.
CREAM VS OINTMENT
The base carries the anesthetics into the skin, and it changes how the same actives behave.
CREAM BASE
A modern transdermal base. It absorbs faster for a quicker onset, spreads smoothly and evenly, and keeps the actives uniformly distributed so every part of the treatment area gets the same dose.
OINTMENT BASE
Mineral oil and polyethylene. It forms a protective layer that keeps the medication in place, supports high concentrations and releases the actives gradually over longer skin contact.
WHAT DRIVES ABSORPTION
Any topical anesthetic can reach the bloodstream. In 2007 the U.S. FDA issued a public health advisory after two women died following laser hair removal; each had applied a high-concentration compounded numbing cream to her legs and wrapped them in plastic. The FDA advises against heavy application over large areas, applying to broken or irritated skin, wrapping treated skin, and applying heat.
SURFACE AREA
The more skin covered, the more total drug is absorbed. Treat large areas in sections or across sessions.
WRAPPING & HEAT
Plastic wrap, dressings and heat all increase absorption. The standard protocol is to rub the cream in and leave it uncovered.
SKIN INTEGRITY
Broken or irritated skin lets more drug through. Apply only to intact skin, and remove the cream completely before any procedure that opens the skin.
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